Invokana Weight Loss Non Diabetic: In proof-of-idea trial, J&J’s Invokana combination enables non-diabetics to shed tremendous weight.
NEW ORLEANS—In diabetes trials, Johnson & Johnson’s Invokana has helped a few sufferers lose weight–now and again greater weight than they did on some other diabetes treatment. Could the drug paintings for weight reduction in sufferers with out diabetes?
The solution changed into sure in a Phase II trial offered Saturday on the American Diabetes Association Scientific Sessions. The proof-of-idea have a look at confirmed that combining Invokana (canagliflozin) with the older weight loss med phentermine introduced a 7.5% lack of frame weight.
The 334-affected person has a look at examined the two-med mixture in opposition to phentermine alone, canagliflozin alone, and a placebo. After 26 weeks, sufferers the use of the mix had misplaced 7.5% in their frame weight, in comparison with 4.1% in the ones taking phentermine alone, 1.9% of these handiest taking canagliflozin, and 0.6% of placebo sufferers.
Also, nearly two-thirds of the sufferers taking each capsules decreased their frame weight through as a minimum 5%, in comparison with 17.5% of placebo sufferers.
“The findings guide the capability medical effect that canagliflozin ought to have at the lives of humans continuously having to manipulate their weight,” stated Dr. James List, worldwide head of cardiovascular and metabolism at J&J’s Janssen unit. “We are devoted to pursuing transformational treatments and desire to develop our know-how of the way canagliflozin may be used to assist greater sufferers withinside the future.”
If shown in large trials, the findings ought to have an economic effect, too. Obesity is an epidemic withinside the U.S., so there’s no scarcity of sufferers wanting assistance to lose weight, and masses of clinical motives to do so, thinking about its hyperlinks to all types of severe diseases.
Pretty new technology of weight loss capsules, however, has had little fulfillment for the reason that first made its debut numerous years ago. Arena Pharmaceuticals’ Belviq, Vivus’ Qsymia, and Orexigen’s Contrave have all struggled to advantage traction, and feature fallen ways quick of preliminary income expectations. These launches have been all a ways from perfect, and that they confronted an uphill climb with docs who frequently turn away from weight loss capsules and payers who frequently refuse to cowl them. But even after Arena advertising companion Eisai positioned loads of reps on Belviq, and signed greater payers directly to the idea, the drug didn’t capture on–to the factor wherein Eisai slashed the scale of its Belviq income force.
J&J’s fellow diabetes drugmaker Novo Nordisk is now withinside the blend with Saxenda, a formula of its diabetes blockbuster Victoza that’s authorized for weight problems. That drug has been gradual to construct as properly, however, Novo sees sufficient promise withinside the weight problems discipline that it has installation a weight problems-targeted R&D middle in Seattle.
Of course, Janssen might must take an Invokana mixture into Phase III–and succeed–with the intention to practice for FDA approval, after which a release might come to a while after that. But with weight problems a persevering with the problem, there’s a little hazard that the marketplace might cut back earlier than then.
But Invokana is probably hampered through new cautionary language on its legitimate FDA label. Last fall, the company brought data on approximately capability bone density modifications and fracture risks. Then again, Invokana may have a perceived CV advantage on its side. A rival SGLT2 med, Eli Lilly and Boeringer Ingelheim’s Jardiance, these days confirmed it can stave off CV events, and that properly information is probably spilling over onto the relaxation of that drug class.
In the newly offered have a look at data, the canagliflozin and phentermine mixture introduced a statistically substantial discount in systolic blood pressure, Janssen stated in a release. And the two-drug aggregate changed into “properly tolerated” without a new or sudden protection signal.